MSDS Number: B5380 * * * * * Effective Date: 03/14/07 * * * * *
Supercedes: 08/10/04

BROMOTHYMOL BLUE

1. Product Identification

Synonyms: 3,3',-Dibromothymolsulfonphthalein; 4,4'-(3H-2,1
Benzoxathiol-3-ylidene) bis [2 bromo-3-methyl-6-(1-methylethyl)phenol]
S,S-dioxide
CAS No.: 76-59-5
Molecular Weight: 624.38

Chemical Formula: C27H28Br2O5S
Product Codes: D470

2. Composition/Information on Ingredients

Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------------ ---------

Bromothymol Blue 76-59-5 90 - 100% Yes

3. Hazards Identification

Emergency Overview
--------------------------

CAUTION! MAY BE HARMFUL IF SWALLOWED. MAY CAUSE IRRITATION TO SKIN,
EYES, AND RESPIRATORY TRACT.

SAF-T-DATA(tm)
Ratings (Provided here for your convenience)

-----------------------------------------------------------------------------------------------------------

Health Rating: 1 - Slight
Flammability Rating: 1 - Slight

Reactivity Rating: 1 - Slight
Contact Rating: 1 - Slight
Lab
Protective Equip: GOGGLES; LAB COAT; PROPER GLOVES
Storage Color Code:
Green (General Storage)

Potential Health Effects
----------------------------------

Limited health information was found in the published literature to
perform a complete hazard evaluation for this substance. Special precautions
must be used in handling and storage. Protective equipment should be chosen
using professional judgment.

Inhalation:
No specific
information found. Probably irritating to respiratory tract.

Ingestion:
Effects not determined. Probably irritating to the
gastro-intestinal tract.
Skin Contact:
No specific information
found. Probably irritating to moist skin.
Eye Contact:
No
specific information found. Probably irritating to eye tissues.
Chronic
Exposure:
Not determined.
Aggravation of Pre-existing
Conditions:
No information found.

4. First Aid Measures

Inhalation:
Remove to fresh air. Get medical attention
for any breathing difficulty.
Ingestion:
Induce vomiting
immediately as directed by medical personnel. Never give anything by mouth to
an unconscious person.
Skin Contact:
Remove any contaminated
clothing. Wash skin with soap or mild detergent and water for at least 15
minutes. Get medical attention if irritation develops or persists.
Eye
Contact:
Wash eyes with plenty of water for at least 15 minutes. Call
a physician.

5. Fire Fighting Measures

Fire:
As with most organic solids, fire is possible at
elevated temperatures or by contact with an ignition source.

Explosion:
Fine dust dispersed in air in sufficient
concentrations, and in the presence of an ignition source is a potential dust
explosion hazard.
Fire Extinguishing Media:
Water spray, dry
chemical, alcohol foam, or carbon dioxide.
Special Information:

In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full facepiece operated in the
pressure demand or other positive pressure mode.

6. Accidental Release Measures

Remove all sources of ignition. Ventilate area of leak or spill.
Wear appropriate personal protective equipment as specified in Section 8.
Spills: Clean up spills in a manner that does not disperse dust into the air.
Use non-sparking tools and equipment. Reduce airborne dust and prevent
scattering by moistening with water. Pick up spill for recovery or disposal
and place in a closed container.

7. Handling and Storage

Keep in a tightly closed container. Protect from physical damage.
Store in a cool, dry, ventilated area away from sources of heat, moisture and
incompatibilities. Containers of this material may be hazardous when empty
since they retain product residues (dust, solids); observe all warnings and
precautions listed for the product.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits:
None established.

Ventilation System:
A system of local and/or general exhaust is
recommended to keep employee exposures as low as possible. Local exhaust
ventilation is generally preferred because it can control the emissions of the
contaminant at its source, preventing dispersion of it into the general work
area. Please refer to the ACGIH document, Industrial Ventilation, A Manual
of Recommended Practices, most recent edition, for details.

Personal Respirators (NIOSH Approved):
For conditions of use
where exposure to dust or mist is apparent and engineering controls are not
feasible, a particulate respirator (NIOSH type N95 or better filters) may be
worn. If oil particles (e.g. lubricants, cutting fluids, glycerine, etc.) are
present, use a NIOSH type R or P filter. For emergencies or instances where
the exposure levels are not known, use a full-face positive-pressure,
air-supplied respirator. WARNING: Air-purifying respirators do not protect
workers in oxygen-deficient atmospheres.
Skin Protection:

Gloves and lab coat, apron or coveralls.
Eye Protection:

Use chemical safety goggles. Maintain eye wash fountain and quick-drench
facilities in work area.

9. Physical and Chemical Properties

Little information was found in the literature.

Appearance:
Yellow crystals.
Odor:

Characteristic odor.
Solubility:
Very slightly soluble in
water.
Specific Gravity:
No information found.
pH:

No information found.
% Volatiles by volume @ 21C (70F):
0

Boiling Point:
Not applicable.
Melting Point:

200 - 202C (392 - 396F)
Vapor Density (Air=1):
No
information found.
Vapor Pressure (mm Hg):
No information
found.
Evaporation Rate (BuAc=1):
No information found.

10. Stability and Reactivity

Stability:
Stable under ordinary conditions of use and
storage.
Hazardous Decomposition Products:
Burning may produce
bromines, sulfur oxides, carbon dioxide, and carbon monoxide.
Hazardous
Polymerization:
Will not occur.
Incompatibilities:

Strong oxidizers.
Conditions to Avoid:
Incompatibles.

11. Toxicological Information

No LD50/LC50 information found relating to normal routes of
occupational exposure. Investigated as a mutagen.

--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Bromothymol Blue (76-59-5) No No None

12. Ecological Information

Environmental Fate:
No information found.

Environmental Toxicity:
No information found.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be
managed in an appropriate and approved waste disposal facility. Processing,
use or contamination of this product may change the waste management options.
State and local disposal regulations may differ from federal disposal
regulations. Dispose of container and unused contents in accordance with
federal, state and local requirements.

14. Transport Information

Not regulated.

15. Regulatory Information

--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Bromothymol Blue (76-59-5) Yes Yes No Yes

--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Bromothymol Blue (76-59-5) Yes Yes No Yes

--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Bromothymol Blue (76-59-5) No No No No

--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Bromothymol Blue (76-59-5) No No No

Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: No Fire: No Pressure: No
Reactivity: No (Pure / Solid)

Australian Hazchem Code: None allocated.

Poison Schedule: None allocated.
WHMIS:
This MSDS
has been prepared according to the hazard criteria of the Controlled Products
Regulations (CPR) and the MSDS contains all of the information required by the
CPR.

16. Other Information

NFPA Ratings: Health: 1 Flammability: 1
Reactivity: 0
Label Hazard Warning:
CAUTION! MAY BE
HARMFUL IF SWALLOWED. MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY
TRACT.
Label Precautions:
Wash thoroughly after
handling.
Avoid contact with eyes, skin and clothing.
Avoid breathing
dust.
Store in a tightly closed container.
Use with adequate
ventilation.
Label First Aid:
If swallowed, induce vomiting
immediately as directed by medical personnel. Never give anything by mouth to
an unconscious person. In case of contact, immediately flush eyes or skin with
plenty of water for at least 15 minutes. If irritation develops call a
physician. If inhaled, remove to fresh air. Get medical attention for any
breathing difficulty.
Product Use:
Laboratory Reagent.

Revision Information:
MSDS Section(s) changed since last
revision of document include: 3.
Disclaimer:

************************************************************************************************

Mallinckrodt Baker, Inc. provides the information contained herein in
good faith but makes no representation as to its comprehensiveness or
accuracy. This document is intended only as a guide to the appropriate
precautionary handling of the material by a properly trained person using this
product. Individuals receiving the information must exercise their independent
judgment in determining its appropriateness for a particular purpose.
MALLINCKRODT BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER
EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE
INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS.
ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES
RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.

************************************************************************************************

Prepared by: Environmental Health & Safety
Phone Number:
(314) 654-1600 (U.S.A.)